Abstract:
Introduction. Fetal hydrops is defined as the pathological accumulation of extracellular fluid in at least two fetal anatomical compartments, including skin edema (> 5 mm thickness), pericardial effusion, pleural effusion, and ascites. Non-immune fetal hydrops (NIHF) accounts for over 90% of all fetal hydrops cases and has a heterogeneous etiology. Congenital
infections contribute to approximately 6–7% of NIHF cases and are associated with a severe neonatal prognosis.
Case presentation. A preterm newborn was delivered from a pregnancy complicated by untreated maternal primary
syphilis. The fetus had been diagnosed antenatally with NIHF, heart failure, and massive ascites. Postnatally, the infant
required early ascitic drainage and subsequently underwent surgery for congenital intestinal obstruction in the context
of ileal stenosis. Neonatal serological testing revealed a positive rapid plasma reagin (RPR) and a reactive Treponema pallidum Hemagglutination Assay (TPHA). Management of congenital syphilis was carried out according to the standardized
national clinical protocol. The collected data were compared with those reported in the existing literature to assess clinical
significance.
Results. The neonate showed a favorable clinical evolution following multidisciplinary management, including intensive
care support, anti-infective therapy, and surgical correction of the intestinal obstruction. Progressive improvement allowed successful postoperative recovery and discharge in satisfactory condition.
Conclusions. Early identification of the infectious etiology of fetal hydrops is essential for the implementation of appropriate management and the improvement of neonatal outcomes. Close collaboration between maternal–fetal medicine,
neonatology, and pediatric surgery is crucial in managing such complex cases.
