Aplicarea criteriilor sindromului antifosfolipidic obstetrical

Abstract

The antiphospholipid syndrome (APS) is characterized by recurrent arterial and/or venous thrombosis and pregnancy morbidity manifested by early or late losses. Laboratory diagnosis of APS relies on the demonstration of a positive test for antiphospholipid antibodies (aPL). In clinical practice, the gold standard tests are those that detect anticardiolipin antibodies (aCL) and/or the lupus anticoagulant (LA). Although other specificities for aPL have been described their clinical utility and standardization has still to be established. Persistence of aPL positive tests must be demonstrated, and other causes and underlying factors considered. Correct identification of patients with APS is important, because prophylactic anticoagulant therapy can prevent thrombosis from recurring, and treatment of affected women during pregnancy can improve fetal and maternal outcome.

Studierea manifestărilor sindromului antifosfolipidic obstetrical (SAFLo) – afecţiune care se prezintă clinic cu recurenţe de tromboze venoase sau arteriale şi/sau patologie obstetricală. Confirmare de laborator în SAFL sunt nivelurile ridicate de anticorpi anticardiolipinici şi/sau anticoagulantul lupic. Sindromul antifosfolipidic reprezintă un domeniu de interes susţinut şi o problemă cu importante valenţe medico-sociale. Utilizarea criteriilor de diagnostic în SAFLo presupune diagnostic precoce şi tratament adecvat.