Abstract:
AMH has been involved in the pathogenesis of PCOS. The goal of this research was to
measure AMH before and after laparascopic ovarian drilling and to evaluate its prognosis
regarding ovulatory respons, to investigate AMH changes and other hormonal disturbunces after
LOD, to explore the effects of LOD further. This prospective study included anovulatory
women with PCOS undergoing LOD (n= 40). Plasma AMH concentrations were measured
before and 5 days after surgical treatment. The pretreatment plasma AMH concentrations were
6,2 (1,0-21,0) ng/ml in women having LOD treatment. Women who ovulated after LOD (n= 34)
had a significantly lower preoperative AMH 5.9 ( 1.0 – 7,7) ng/ml compared with the nonresponders
9,6 (8,2 – 21,0) ng/ml. Using receiver-operating characteristic curve analysis, AMH
was found to be a useful predictor of no ovulation after LOD with area under the curve of 0.804
(P=0.025). Using a cut-off of 7.7 ng/ml, AMH had a sensitivity of 78% and a specificity of 76%
in the prediction of no ovulation after LOD. For all patients, plasma AMH7.7 ng/ml was
associated with a reduced chance of ovulation after treatment (P=0.004). Following LOD, the
median AMH concentration significantly (P=0.003) decreased to 4,6 (0,7- 5,4) ng/ml.
АМH a fost implicat în patogeneza sindromului ovarelor polichistice. Scopul acestui
studiu a fost de apreciere a AMH seric înainte şi după drilling ovarian laparascopic şi de
evaluare a unui prognostic ovulator, de a investiga АМH şi alte schimbări hormonale după
drilling ovarian laparascopic. Acest studiu propectiv a inclus pacientele anovulatorii cu acest
sindrom, care au suferit drilling ovarian laparascopic (n= 40). Concentrațiile plasmatice ale
AMH seric au fost măsurate înainte şi 5 zile după tratament chirurgical. Concentrațiile serice
preoperatorii ale AMH au fost de 6,2 (1,0-21,0) ng/ml. Pacientele care au ovulat după drilling
ovarian laparascopic (n= 34) au avut un AMH relativ mic 5.9 ( 1.0 - 7,7) ng/ml, comparativ cu
cele care nu auovulat 9,6 (8,2 - 21,0) ng/ml.Aşadar AMH s-a dovedit a fi un predictor important
al pacientelor care nu vor raspunde nici la drilling ovarian laparascopic. Prin criteriul 7.7 ng/ml,
АМH a avut o sensibilitate de 78% şi o specificitate de 76% în prognosticul pacientelor care nu
vor ovula după tratamentul chirurgical. Pentru toţi pacienţii, plasma AMH7.7 ng/ml, a fost
asociat cu o probabilitate mai mică de ovulatie dupa tratament.După drillingul ovarian
laparascopic concentrația AMH seric semnificativ a scăzut la 4,6 (0,7 - 5,4) ng/ml.
