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In vivo evaluation of xenogeneic acellular bovine fascia grafts in the reconstruction of abdominal wall defects in swine experimental model

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dc.contributor.author Negru, I.
dc.date.accessioned 2019-06-26T04:42:14Z
dc.date.available 2019-06-26T04:42:14Z
dc.date.issued 2017
dc.identifier.issn 2587-3229
dc.identifier.issn 2587-3210
dc.identifier.uri http://www.sncprm.info.md/getArticle/2018-01-06_15-01-49_-art%2012.compressed.pdf
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/5489
dc.description Public Institution State University of Medicine and Pharmacy “Nicolae Testemiţanu”, PMSI Mother and Child Institute, Chisinau, Republic of Moldova en_US
dc.description.abstract ABSTRACT In this study autor purpose to evaluate the feasibility of using bovine fascia in the experimental substitution of the fascial plan for the reconstruction of major anterior abdominal wall defects in the experimental model. Plastic reconstruction of the surgically induced abdominal wall defect using decellularized bovine fascia grafts was performed on 5-week-old Landrace pigs (3 animals) in which the abdominal wall defect of 10x5.0 cm was surgically induced with the involvement of all layers, including the peritoneum. The animals were subsequently euthanized 90 days after the intervention. For decellularization, sterile 0.5% SDS solution (HiMedia) was used in volume required to obtain acellular tissues. The solution was changed every 24 hours for 72 hours. The preventive results of the histopathological examination allowed the author to conclude that the use of decellularized bovine fascia grafts in the experimental model is characterized by the dominance of active regenerative processes with tissue remodeling and host cell invasion, the xenogeneic implant tissues being subjected to gradual degradation and substituted with the neoformed host connective tissue, the rationale of the usefulness of this biological material requiring additional comparative and clinical immunological studies. The results of this experimental study allow us to conclude the following that the usage of bovine fascia acellular grafts as an alternative xenogeneic biological implant in reconstructive surgery of abdominal wall defects, this option requiring additional comparative and clinical immunological studies. en_US
dc.language.iso en en_US
dc.publisher Moldavian Journal of Pediatric Surgery en_US
dc.subject Bioimplant en_US
dc.subject Acellular Grafts en_US
dc.subject Bovine Fascia en_US
dc.subject Reconstructive Surgery en_US
dc.subject.mesh Transplants en_US
dc.subject.mesh Fascia en_US
dc.subject.mesh Reconstructive Surgical Procedures en_US
dc.title In vivo evaluation of xenogeneic acellular bovine fascia grafts in the reconstruction of abdominal wall defects in swine experimental model en_US
dc.type Article en_US
dc.rights.holder © National Society of Pediatric Surgery of the Republic of Moldova, 2017


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