Abstract:
The study describes the antibiotic resistance of causative agents of purulent septic infections in patients of hospitals of ortopedic and traumatological
profile. It includes 1269 patients from whom 2013 strains of microorganisms have been isolated. As a result of the analysis of antibiograms, a high
resistance of strains to antibiotics have been detected (50.16%), including gram-negative microorganisms – 57.72% and gram-positive ones – 46.09%.
A high level of antibiotic resistance has been identified in such microorganisms as Acinetobacter (85.72%), E. cloacae (71.43%), C. diversus (64.78%),
K. pneumoniae (64.54%) and P. aeruginosa (62.78%). Depending on the antibiotic group, a higher resistance of these strains to penicillins (63.95%),
cephalosporins (66.15%) and, especially, to the third generation of cephalosporins (69.35%) has been detected. Purulent septic pathology in hospitals
of ortopedic and traumatological profile is of poly-etiologic nature and characterized by a high resistance of the pathogen agents to antibiotics. At the
same time, the sensitivity/resistance of the causative agents is very diverse, the values of which, depending on the group of antibiotics, are from 29.0 to
97.0% – sensitive, and vice versa, from 26.0 up to 98.0% – resistant. A high resistance to antibiotics has been established in gram-negative microorganisms
(57.72%), including Acinetobacter (85.72%), E. cloacae (free 71.43%), C. diversus (64.78%), K. pneumoniae (64.54%), P. aeruginosa (62.78%), in particular,
to penicillins and cephalosporins, the antibiotics widely used in medical practice. The results of the study demonstrate the need for the development and
implementation of the programme on surveillance and control of microbial antibiotic resistance suitable to a medical hospital.
Description:
Department of Epidemiology, Nicolae Testemitsanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
