Prezenţa concomitentă a dispepsiei funcţionale (DF) şi a
bolii de refl ux neeroziv (BRNE) poartă denumirea de „sindrom încrucişat” (overlap sindrome, DF/BRNE). Drept
material de cercetare au servit rezultatele examinării clinice
şi ale tratamentului a 175 de pacienţi cu DF/BRNE. Au
fost determinate diverse variante clinice ale sindromului
încrucişat respectiv.
Am determinat că cea mai eficientă schemă de tratament al
pacienţilor cu acest sindrom încrucişat este cea care ţine
cont de varianta DF/BRNE şi de diversitatea mecanismelor
patofiziologice de apariţie a simptomelor maladiei.
The presence of two joint disease, functional dyspepsia (FD)
and non-erosive refl ux disease (NERD) at the same time,
has been called overlap syndrome, FD/NERD. There are
no clear criteria for diagnosing FD/NERD, limited data
evidence-based medicine for the treatment with FD/NERD
make extremely urgent further study of this disease.
The material of the study were the results of clinical examination and treatment of 175 patients with non-erosive reflux
disease, combined with functional dyspepsia. Highlighted
clinical variants of cross syndrome (FD/NERD) Hp positive
and Hp negative, as well as options that are determined
at pH monitoring of the esophagus when the clinical
symptoms of FD and/or NERD appeared in pathological
acid gastroesophageal refl ux (AET+SI+) or physiological
acidic gastroesophageal refl ux (AET-SI+). We found that
the most effective treatment regimen of patients with cross
syndrome (FD/NERD) is a scheme depending on the variant
FD/NERD into account the diversity of pathophysiological
mechanisms of disease symptoms. The regimens not only
improves the clinical manifestations of the disease, but also
normalize gastric motility, improve the psycho-emotional
status, and normalize the number of episodes of gastroesophageal reflux and gastric function acidogenic.
