Actuality of high quality histological maintenance in toxicology laboratories in GLP

Abstract

At L.I. Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety, Ministry of Health, Ukraine, over recent years on the base of morphological laboratory is adjusted a standard of GLP system. It has become urgent to unify experiments, to plan their clearly, proper conduct and thereby achieve the certainty of the results. The modern morphology has a complex of techniques, allowing to decide the issues of changes that occur at the tissue level. First of all, it are histological methods, also histochemistry, histoimunology, morphometry etc. For efficient and safe operation, the routine and histological research practice requires the use of the latest technology, required high technical equipment of laboratory with modern equipment. In the laboratory of the Center uses the automated equipment for processing of biological tissues, whose main advantages are: high quality of processing, saving time due to one-stage operation with many preparation, storage programs of procedures in the device thereby increasing the speed and effectiveness of studies, decreasing sharply the particle of defective and damaged samples, which increases the reliability of the results of microscopy. In the laboratory implemented the system of storage samples and documentation. The special rooms are equipped for archive with limited and controlled access. Due to the integration at any time you can control and transfer the information to the laboratory information management system, and thereby ensure the total traceability and recovery of all phases of the study, which is one of the main tasks of the GLP system.