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Particularităţi clinico-paraclinice şi abordări noi în diagnosticul şi tratamentul colitei ulceroase

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dc.contributor.author Ţurcan, Svetlana
dc.date.accessioned 2019-11-25T12:59:02Z
dc.date.available 2019-11-25T12:59:02Z
dc.date.issued 2014
dc.identifier.citation ŢURCAN, Svetlana. Particularităţi clinico-paraclinice şi abordări noi în diagnosticul şi tratamentul colitei ulceroase. In: Sănătate Publică, Economie şi Management în Medicină. 2014, nr. 5(56), pp. 25-33. ISSN 1729-8687. en_US
dc.identifier.issn 1729-8687
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/7173
dc.identifier.uri http://revistaspemm.md/wp-content/uploads/2019/05/cm5_56_2014.pdf
dc.description Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Conferinţa Naţională de Gastroenterologie și Hepatologie cu participare internaţională 20 iunie 2014 Chişinău, Republica Moldova en_US
dc.description.abstract The aim of the study was to analyze demographic, clinical and biological features of ulcerative colitis and improve diagnostic and treatment schemes based on the risk factors of unfavorable evolution of the disease. Prospective cohort study included: 306 patients with ulcerative colitis with follow-up more than 5 years, 172 – more than 10 years and 79 – more than 15 years. Controlled clinical studies were performed for the comparison of different methods of diagnosis and treatment. For the first time were evaluated epidemiological trends and risk factors of ulcerative colitis in Moldova. Patterns of disease and risk factors for an unfavorable evolution were identified. There was shown a possibility to predict disease evolution. A new method of complete remission diagnosis (by evaluation of markers of the oxidative stress) and a new tactic of maintenance therapy (intermittent treatment) were developed. The most significant risk factors: duration until the specific therapy, therapy at disease onset, duration of remission are modifiable factors, therefore, the adequate and timely treatment can improve the disease prognosis. As a result of integrated approach were developed: classification of disease evolution patterns and treatment algorithm based on the risk factors. en_US
dc.description.abstract Цель работы – изучить демографические, клинические и параклинические особенности язвенного колита и усовершенствовать схемы диагностики и лечения в зависимости от факторов риска неблагоприятного течения заболевания. Проспективное когортное исследование включало: 306 пациентов с длительностью наблюдения 5 лет, 172 – 10 лет и 79 больных, наблюдаемых в течение 15 лет. Для сравнения различных методов диагностики и лечения были проведены контролируемые клинические исследования. Впервые оценены эпидемиологические тенденции и факторы риска возникновения язвенного колита в Молдове. Определены закономерности течения заболевания и факторы риска неблагоприятной эволюции и показана возможность прогнозирования эволюции заболевания. Разработаны новая методика диагностики полной ремиссии заболевания (методом оценки маркеров оксидативного стресса) и новая тактика поддерживающей терапии (интермитирующая поддерживающая терапия). В результате комплексного подхода разработаны классификация вариантов течения язвенного колита и алгоритм ведения в зависимости от факторов риска
dc.language.iso ro en_US
dc.publisher Asociația Obștească ”Economie, Management și Psihologie în Medicină” din Republica Moldova en_US
dc.subject ulcerative colitis en_US
dc.subject diagnosis en_US
dc.subject treatment en_US
dc.subject risk factors en_US
dc.subject.mesh Colitis, Ulcerative--diagnosis en_US
dc.subject.mesh Colitis, Ulcerative--physiopathology en_US
dc.subject.mesh Colitis, Ulcerative--pathology en_US
dc.subject.mesh Colitis, Ulcerative--metabolism en_US
dc.subject.mesh Colonoscopy en_US
dc.subject.mesh Colitis, Ulcerative--therapy en_US
dc.subject.mesh Colitis, Ulcerative--drug therapy en_US
dc.subject.mesh Risk Factors en_US
dc.title Particularităţi clinico-paraclinice şi abordări noi în diagnosticul şi tratamentul colitei ulceroase en_US
dc.title.alternative Clinical and laboratory features and new approaches to diagnosis and treatment of ulcerative colitis en_US
dc.title.alternative Клинико-параклинические особенности и новые подходы к диагностике и лечению язвенного колита en_US
dc.type Article en_US


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