Evaluarea efectului imunomodulator al Pacovirinei la femeile vaccinate contra hepatitei virale B

Abstract

Background: In the article have been shown the results of the use of the autochthonous vegetal product Pacovirin with antiviral, immunomodulatory and antioxidant effects in women of reproductive age with immune deficiency, vaccinated against hepatitis B, to increase the process of immunogenesis and protective titers of antibodies to hepatitis B. Material and methods: The immune status has been assessed on the basis of the ratio Th indicator Th (CD4ml/Ts (CD8ml). Totaly, the study has included 80 women of reproductive age including 40 in the experimental group and 40 in the control group. To determine the presence of antibodies to the virus of hepatitis B the enzyme-linked immunosorbent assay (ELISA) has been used with the specifics of 99.5% and the sensitivity of 99.8%, manufacturer – the company Bio-Rad, France. Subclasses of T-lymphocytes (Th, CD4 and Ts CD8) have been identified and evaluated through Capcellia test and the method of sockets in the presence of theophylline Results: Overall in the experimental group we achieved an immune response in 95.0 ± 3.4% of the cases and in the control group only 67.5 ± 7.4% of women developed an immune response durable The results of this study may serve in the future as an important element in the change of the strategy of vaccination of persons with immune deficiency, especially the women of childbearing age – with the vaccine against viral hepatitis B, where Pacovirin will serve as a supplement with immunomodulatory effect. These results will be implemented in the course of the new National Program for the struggle against viral hepatitis B, C and D in the period of 2012-2016, approved by Government Decree № 90 dated by 13.02.2012. Conclusions: Vaccination against HBV of women of childbearing age with compromised immune status, with concomitant administration of Pacovirin significantly increases efficiency and minimizes risk to get sick with HBV in the category of women said.