Importanţa imunostimulării locale în tratamentul conservator complex al amigdalitei cronice la copii

Abstract

Background: Chronic respiratory infections affect the particularitation of general immune system, impaired local immunity and increased frequency of allergic diseases. The methods used in the treatment of chronic tonsillitis are not effective enough and now it is required developing new diagnostic criteria and reasonable tactics complex conservative therapy. Modern methods of treatment of chronic tonsillitis are oriented to normalization of general immune status of the body, restoring the function of drainage gaps tonsil, hypo-sensitization, and decreased symptoms of local inflammation. Material and methods: The children with compensated chronic tonsillitis were divided into two groups: 26 patients (1-st group) were subjected to therapeutic traditional treatment and immunomodulatory local treatment with application of activated mononuclear autocells and 26 patients (2-nd group), that have been treated by traditional therapeutic method. All patients were tested: the functional activity of neutrophils in nitro-blue tetrazolium test (NBT); the content of phagocytic neutrophils and their phagocytic activity; total hemolytic activity of the complement; normal antibody titer, lymphocyte subpopulations were determinated by immunofluorescence using monoclonal antibodies reaction; the level of immunoglobulins; the content of circulating immune complexes; ASL-O rheumatoid factor; reactive protein – C; blast transformation reaction of lymphocytes with phytohaemaglutinin. The smear was taken from the patients and the bacterial flora and its susceptibility to antibiotics before and after the conservative treatment was investigated. Results: After treatment, in 1-st group comparativly 2-nd group, was appreciated a more pronounced decrease in the levels of indexes CIC, IgE, CD-4/CD-8 antigens streptococcus sensitivity and a greater increase of phagocytic activity and the number of neutrophils, the functional activity of T-lymphocytes. Conclusions: Thanks to investigations of preimmune reactivity and immunological changes in the body in case of compensated chronic tonsillitis in children was appreciated the effectiveness of conservative treatment with topical application of complex activated mononuclear autolimfocite that has a positive effect with clinical and immunological high level.