Abstract:
The purpose of our research is to study the in vitro action of the drugs BioR and BioRZn (a complex of essential bioactive zinc components in spirulina) on the clinical picture and full functional activity of T-lymphocytes, depending on the adverse effects of antituberculosis drugs. For processing
the materials the operating methods of statistical estimation, including the Student’s criterion, Windows 2007 software, etc. have been used. The study
has included 110 patients of both sexes with various forms of pulmonary tuberculosis. Depending on the reaction to anti-tuberculosis preparations, the
patients were divided into three groups: 1) allergic reaction (AR) – 37 patients, 2) toxic-allergic reactions (TAR) – 49 patients and 3) the patients with
toxic reaction (TR) – 24 people. To characterize the state of proliferation activity of T lymphocytes the reaction of blast transformation of lymphocytes
with phytohaemaglutinin has been used. The patients with allergic, toxic-allergic and toxic reactions on antituberculosis preparations have demonstrated
clinical and laboratory differences, that confirm the severe disease progression in the patients with toxic reactions and less severe disease progression in
the patients with allergic reactions. BioR preparations and, especially, BioRZn present the immunomodulatory action of T lymphocytes ”in vitro”. The
lower the level of proliferation activity of T lymphocytes in patients is, the higher the immunomodulatory activity of preparations BioR and, in particular,
BioRZn in the process of proliferation of T lymphocytes and vice versa is.
