Abstract:
An evaluation was conducted of herpetic infections and clinical
and immunological features in wheezy children. The study group
included 54 children with recurrent wheezing, who were admitted
to the Public Medical and Sanitary Institution Children’s Municipal Clinical Hospital No. 1 in 2008-2009. Patients were divided
into 3 groups according to the age: group 1 – children aged 0-12
months (18.8%), group 2 – 12-24 months of age (62.9%), and
group 3 – 24-36 months (18.3%). The herpetic infection diagnosis
was confirmed by the following examination methods: PCR (polymerase chain reaction) and the immunoenzymatic technique.
Humoral immunity was assessed using the Mancini method and
cell-mediated immunity was assessed using sheep erythrocytes. All
patients included in the study had positive family epidemiological anamnesis of herpetic infections. Analysis of the results was carried
out by means of the medical statistical method.
Children with herpetic infections are at a major risk of recurrent wheezing. All examined children had mixed forms of herpetic
infections (Herpes simplex virus+Cytomegalovirus). Association of
the acute renal failure with Herpes simplex virus+Cytomegalovirus
infections has facilitated the apparition of secondary humoral
and cell-mediated immunological disorders (decrease of CD3,
CD-4, CD8, and CD-20 levels and also immunoglobulin A and
G fractions).
Description:
Department of Pediatrics, Nicolae Testemitanu State Medical and Pharmaceutical University, Congresul III al Medicilor de Familie din Republica Moldova, 17–18 mai, 2012, Chişinău, Republica Moldova, Conferinţa Naţională „Maladii bronhoobstructive la copii”, consacrată profesorului universitar, doctor habilitat Victor Gheţeul, 27 aprilie, Chişinău, Republica Moldova
