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Combined therapeutic approach in acute coronary syndrome patients under environmentally unfriendly working conditions

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dc.contributor.author Agaev, Mamedgasan
dc.contributor.author Agaeva, Tarana
dc.date.accessioned 2020-05-26T05:50:12Z
dc.date.available 2020-05-26T05:50:12Z
dc.date.issued 2020
dc.identifier.citation AGAEV, Mamedgasan, AGAEVA, Tarana. Combined therapeutic approach in acute coronary syndrome patients under environmentally unfriendly working conditions. In: The Moldovan Medical Journal. 2020, vol. 63, no 1, pp. 8-12. ISSN 2537-6373. DOI: 10.5281/zenodo.3685644 en_US
dc.identifier.issn 2537-6373
dc.identifier.issn 2537-6381
dc.identifier.uri http://moldmedjournal.md/wp-content/uploads/2020/06/Mold-Med-J-March-2020-Vol-63-No-1-Full-Issue-version-5-of-10-06-20.pdf
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/9825
dc.identifier.uri https://doi.org/10.5281/zenodo.3685644
dc.description Department of Cardiology, Azerbaijan Medical University, Baku, Azerbaijan, D. M. Abdulaev Institute of Cardiology, Baku, Azerbaijan en_US
dc.description.abstract Background: The purpose of this study was to assess the effectiveness of the combined use of high doses of heparin, propranolol and monopril with percutaneous coronary intervention (PCI) on eco-endotoxicosis, systolic blood pressure, diastolic blood pressure, heart rate (HR), cardiodynamics and on the clinical course in acute myocardial infarction (AMI) among patients working in environmentally unfriendly conditions. Material and methods: The study was conducted on 42 patients, aged 30 to 70 years (56.7 ± 1.20 years) with acute coronary syndrome (ACS), who were assessed for the anterior Q wave MI and ST segment elevation MI. Of 42 patients, 21 were treated with monopril, propranolol with heparin and PCI (group 1); and 21 patients underwent only PCI (group 2). The degree of eco-endotoxicosis in blood was studied in both groups, whereas the echocardiography and Doppler echocardiography were used to determine the end-systolic volume (ESV), end-diastolic volume (EDV), left ventricular ejection fraction (LV EF), local LV contractile dysfunction, local contractile dysfunction index (LCDI), restenosis via a repeated coronary angiography, echographic study of ST segment elevation and of repeated anginal pain. Results: Patients treated with monopril with propranolol and heparin with PCI exhibited a stabilization of central hemodynamic indices, by a decrease in ESV, EDV, LCDI, and the degree of eco-endotoxicosis, as well as an improvement of LV systolic function by an increased EF. However, one patient from this group had an acute heart failure (AHF) on the 3rd day, whereas one patient experienced a MI relapse. The group of patients who underwent only PCI, revealed 3 cases of MI recurrence, 3 cases of restenosis, 2 cases of AHF and 2 patients died. Conclusions: The combined use of drug and PCI therapy in acute coronary syndrome might lead to positive prognostic outcomes, rather than a separate PCI approach. en_US
dc.language.iso en en_US
dc.publisher The Scientific Medical Association of the Republic of Moldova en_US
dc.relation.ispartof The Moldovan Medical Journal
dc.subject ecology en_US
dc.subject acute coronary syndrome en_US
dc.subject hemodynamics en_US
dc.subject percutaneous coronary intervention en_US
dc.subject.ddc percutaneous coronary intervention en_US
dc.subject.ddc UDC: 616.132.2-007.272:615.273.53
dc.subject.mesh Ecology en_US
dc.subject.mesh Acute Coronary Syndrome--etiology en_US
dc.subject.mesh Acute Coronary Syndrome--physiopathology en_US
dc.subject.mesh Hemodynamics en_US
dc.subject.mesh Percutaneous Coronary Intervention en_US
dc.subject.mesh Myocardial Revascularization en_US
dc.subject.mesh Environmental Exposure en_US
dc.subject.mesh Environmental Illness en_US
dc.title Combined therapeutic approach in acute coronary syndrome patients under environmentally unfriendly working conditions en_US
dc.type Article en_US


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