Institutional Repository in Medical Sciences
(IRMS – Nicolae Testemițanu SUMPh)

Automatic amperometric titration method for quantitative determination of zinc oxide in ointments

Show simple item record

dc.contributor.author Oprea, Vasile
dc.contributor.author Valica, Vladimir
dc.contributor.author Cheptanaru, Constantin
dc.contributor.author Nistorica, Mihai
dc.contributor.author Oprea, Sergiu
dc.contributor.author Movila, Liviu
dc.date.accessioned 2020-05-26T05:57:42Z
dc.date.available 2020-05-26T05:57:42Z
dc.date.issued 2020
dc.identifier.citation OPREA, Vasile, VALICA, Vladimir, CHEPTANARU, Constantin, et al. Automatic amperometric titration method for quantitative determination of zinc oxide in ointments. In: The Moldovan Medical Journal. 2020, vol. 63, no 1, pp. 13-18. ISSN 2537-6373. DOI: 10.5281/zenodo.3685650 en_US
dc.identifier.issn 2537-6373
dc.identifier.issn 2537-6381
dc.identifier.uri http://moldmedjournal.md/wp-content/uploads/2020/06/Mold-Med-J-March-2020-Vol-63-No-1-Full-Issue-version-5-of-10-06-20.pdf
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/9826
dc.identifier.uri https://doi.org/10.5281/zenodo.3685650
dc.description Department of General Chemistry, Department of Pharmaceutical Chemistry and Toxicology, Scientific Center for Drug Research, Nicolae Testemitsanu State University of Medicine and Pharmacy, Medicines and Medical Devices Agency, Chisinau, the Republic of Moldova, Department of Informatics and Information Management, Academy of Economic Studies of Moldova Chisinau, the Republic of Moldova en_US
dc.description.abstract Background: Zinc is an important trace mineral in human body, therefore development of new methods for zinc determination in drugs is an actual task. Material and methods: Assay of standard solutions of zinc ions and solutions of ointments to be analyzed was performed automatically using the titrator TITRION, which recorded, then displayed on the screen each amperometric titration curve. The titration curves had a sudden break in the current intensity at the equivalence point, caused by anodic oxidation of the titrant and cathodic reduction of H+ at pH 3 – 4. The stoichiometry of Zn2+ ion sedimentation reaction with [Fe(CN)6 ]4- ions was studied and confirmed in the presence of the background electrolyte and the ZnO calculation formulas in the analyzed ointments were deduced. Results: Two different ointment masses were weighed for the Zoxitin ointment and the separate calculation results were 0.4172±0.0051 g/g and 0.4212±0.0051 g/g of ointment, and in the zinc oxide ointment ω(ZnO) was 10.208±0.078 %.These results were compared with the results of ZnO analysis in ointment by the classical complexometric titration method. For the Zoxitin ointment m(ZnO) was 0.4223±0.007 g/g of ointment, and for the ointment with ZnO ω(ZnO) was 10.18±0.11%. Conclusions: An automatic amperometric titration method was developed to quantify ZnO in ointments. The method is based on the sedimentation reaction of zinc ions with potassium ferrocyanide solution in presence of acetate buffer solution as background electrolyte. en_US
dc.language.iso en en_US
dc.publisher The Scientific Medical Association of the Republic of Moldova en_US
dc.relation.ispartof The Moldovan Medical Journal
dc.subject automatic amperometric titration en_US
dc.subject zinc oxide en_US
dc.subject quantitative determination of Zn en_US
dc.subject.ddc UDC: 615.454.1.074:546.47-31+543.553.4 en_US
dc.subject.mesh Zinc Oxide en_US
dc.subject.mesh Oxides en_US
dc.subject.mesh Ointments--chemistry en_US
dc.subject.mesh Pharmaceutical Preparations en_US
dc.subject.mesh Pharmacology en_US
dc.subject.mesh Quality Control en_US
dc.title Automatic amperometric titration method for quantitative determination of zinc oxide in ointments en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics