Abstract:
Background: Enterobacteria can produce enzymes (ESBLs) to inactivate beta-lactamins and can also be resistant to carbapenems
(CRE), as superbugs.
Objective: To evaluate the superbacteria frequency in the last two years in Arad County Clinical Hospital.
Material and methods: The multidrug criteria described in Clinical Microbiology and Infection Volume 18, Issue 3, 2011
were used. VITEK and E-test for ESBLs and diffusometric anti-biograms methods for CRE were used, interpreted according
to EUCAST and CLSI.
Results: Were identified 5093 isolates, 67.85% were Gram negative (n = 3456), 2905 were enterobacteria (57.03% of total,
84.05% of Gram negatives). ESBLs represent 19.53% (n = 995), 15.2% (n = 151) in Surgical wards, 14.94% (n = 149) on ICU
and 12.8% (n = 127) in Internal Medicine departments; they were present in all 24 hospital wards, colonizing even ambulatory
patients (n = 32; 3.2%). Superbugs were 117 of these, most of which were present on ICUs (n = 57; 48.7%), Neurology (n = 15;
12.8%), Surgery (n=15; 12.8%) and Palliative (n = 12; 10.3%). Most multidrug resistant organisms were Klebsiella pneumoniae
(n = 58; 49.6%), Proteus spp (n = 28; 23.91%) and Providencia stuartti (n = 19; 16.2%).
Conclusions: Enterobacteria with extended resistance to cephalosporins and carbapenems were identified in the last two years
in this hospital, especially in the ICU, Surgical and Internal Medicine departments, colonizing ambulatory patients as well. They
are in the WHO alert, along with other Gram negative species, as Acinetobacter baumannii and Pseudomonas aeruginosa.
Description:
CHU Reunion, France, Vasile Goldis Western University of Arad, Romania, Arad County Clinical Hospital, Romania, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania, The 5th International Congress of the Society of Anesthesiology and Reanimatology of the Republic of Moldova, 16th Edition of the International Course of Guidelines and Protocols in Anesthesia, Intensive Care and Emergency Medicine, 28th Meeting of the European Society for Computing and Technology in Anesthesia and Intensive Care September 27-29, 2018, Chisinau, the Republic of Moldova