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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/7147
Title: Determinarea spectrofotometrică a codeinei din comprimate
Other Titles: Spectrophotometric determination of codeine in tablet dosage
Спектрофотометрическое определение кодеина в таблетках
Authors: Corciovă, Andreia
Ciobanu, Constantin
Keywords: codeine phosphate;bromphenol blue;ion-pair complex
Issue Date: 2014
Publisher: Asociația Obștească ”Economie, Management și Psihologie în Medicină” din Republica Moldova
Citation: CORCIOVĂ, Andreia, CIOBANU, Constantin. Determinarea spectrofotometrică a codeinei din comprimate. In: Sănătate Publică, Economie şi Management în Medicină. 2014, nr. 6(57), pp. 31-33. ISSN 1729-8687.
Abstract: A spectrophotometric method for the determination of codeine phosphate in tablet dosage forms has been described, based on the codeine ability to form with bromphenol blue in acidic media, a complex extractible in chloroform. The absorbance of the formed ion-pair complex was monitored spectrophotometrically at 413 nm. The range of linearity for the obtained complex was found to be 0.1–0.5 mg/ml. The proposed method has been successfully applied for the determination of codeine in industrial pharmaceutical forms
В данной статье представлен один из методов спектрофотометрического определения кодеина фосфата в таблетках, который основан на способности образовывать с бромфеноловым синем в кислой среде комплексное соединение, извлекаемое в хлороформе. Оптическую плотность образованного комплекса измеряли при длине волны 413 нм. Аналитический ответ был линейным в интервале концентраций 0,1 – 0,5 мг/ мл. Предлагаемый способ был успешно применен для определения фосфата кодеина в фармацевтических препаратах, производимых промышленным способом.
URI: http://repository.usmf.md/handle/20.500.12710/7147
http://revistaspemm.md/wp-content/uploads/2019/05/cm6_57_2014.pdf
ISSN: 1729-8687
Appears in Collections:Sănătate Publică, Economie şi Management în Medicină Nr. 6 (57) / 2014

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