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- IRMS - Nicolae Testemitanu SUMPh
- REVISTE MEDICALE NEINSTITUȚIONALE
- The Moldovan Medical Journal
- Curierul Medical 2009 - 2016
- Curierul Medical, 2016
- Curierul Medical, 2016, Vol. 59, No 4
Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12710/2937
Title: | Molecular–genetic assay results and clinical, radiological features in patients with pulmonary tuberculosis |
Authors: | Malic, Alina |
Keywords: | pulmonary tuberculosis;genetic assay results;Xpert MTB/RIF |
Issue Date: | 2016 |
Publisher: | Ministerul Sănătăţii al Republicii Moldova, Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” |
Citation: | MALIC, Alina. Molecular–genetic assay results and clinical, radiological features in patients with pulmonary tuberculosis. In: Curierul Medical. 2016, vol. 59, no 4, pp. 2-5. ISSN 1875-0666. |
Abstract: | Background: Early diagnosis of smear-negative and multidrug-resistant tuberculosis represents a national priority, considering the fact that the Republic
of Moldova ranks in the list of 30 high burden multidrug-resistance tuberculosis countries, with 26% rate of primary drug-resistance and 64% acquired
drug-resistance. In April 2012 it was implemented the real-time fully automated diagnostic molecular test in 15 Moldovan districts and penitentiary
institutions. The new assay leads to enhance the tuberculosis early diagnosis, especially multidrug resistant tuberculosis.
Material and methods: A retrospective, selective, descriptive and case-control study was performed using 361 new pulmonary tuberculosis patients,
diagnosed and hospitalized in the Municipal Clinical Hospital of Phthysiopneumology of Chisinau city in the period of 01.01.2014-01.01.2015. The
total sample was distributed in 2 groups: first group included 174 patients with pulmonary tuberculosis assessed by positive Xpert MTB/RIF assay and
the second group included 187 patients with pulmonary tuberculosis assessed having negative Xpert MTB/RIF assay. Investigations were performed
according to the National Clinical Protocols.
Results: The biggest rate of patients included in the research was detected by passive way, in the frame of examination of the symtomatic case: 111 (63.8%)
patients of the 1st Group comparing with 87 (46.5%) in the 2nd Group, p<0.001.
Conclusions: The use of Xpert MTB/RIF technique must be improved in municipality Chisinau for achieving the international quality standards. |
metadata.dc.relation.ispartof: | Curierul Medical |
URI: | http://moldmedjournal.md/wp-content/uploads/2016/09/Cm-4-2016-PDF.pdf http://repository.usmf.md/handle/20.500.12710/2937 |
ISSN: | 1857-0666 |
Appears in Collections: | Curierul Medical, 2016, Vol. 59, No 4
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