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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/3190
Title: Investigaţii chimico-toxicologice asupra metoclopramidei
Other Titles: Chemico-toxicological investigations on methoclopramide
Authors: Hangan, Mariana
Cotelea, Tamara
Soloviov, Larisa
Issue Date: 2008
Publisher: CEP "Medicina"
Citation: HANGAN, Mariana, COTELEA, Tamara, SOLOVIOV, Larisa. Investigaţii chimico-toxicologice asupra metoclopramidei. In: Anale Științifice ale USMF “Nicolae Testemiţanu”. Ed. a 9-a. Chișinău: CEP Medicina, 2008, vol. 1: Probleme medico-biologice şi farmaceutice, pp. 302-305.
Abstract: We elaborated the TLC method of methoclopramide identification by using two developped systems, specrophotometric method of quantitative determination for methoclopramide in powder and tablets of 0.01g. Using the analytical methods elaborated by us over the artificial test there was extracted metoclopramide from biological liquids (plasma, urine). The output of methoclopramede from plasma was 50.44%; from urine- 46.80% Having considered the elaborated methods as specific and reproductive they are recommended for the study of methoclopramide in biological liquids. A fost elaborată metoda cromatografiei pe strat subţire de identificare a metoclopramidei, utilizând 2 sisteme de solvenţi,metoda spectrofotometrică de dozare în pulbere şi comrimate 0,01g. Aplicând metodele analitice elaborate de noi la probele biologice în „vitro” s-a efectuat extracţia metoclopramidei din lichidele biologice. Randamentul metoclopramidei din plasma sanguină este de 50,44%, din urină-46,80%. Dat fiind faptul, că metodele folosite sunt specifice şi reproductive ele se recomandă pentru studierea metoclpramidei în lichidele biologice.
URI: http://repository.usmf.md/handle/20.500.12710/3190
Appears in Collections:Chimie generală și farmaceutică

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