Abstract:
Introduction. Despite the modern medicine benefits, the significant increase of mycotic
infection is caused by a large number of determinant factors that convert the saprophytic
Candida flora into a pathogenic one. The immune system suppression induced by administration
of antibiotics, cytostatics drugs and glucocorticoids have determined an increment in incidence
of oral candidosis, considered by Wenzel an “illness produced by treatment”. Although there is a
large number of antimycotic drugs, selecting a rational remedy is still a key problem for
pharmacotherapy. In order to investigate these aspects, we studied the clinical features of oral
candidosis and evaluated the obtained results of a complete antimycotic treatment.
Materials and methods. 20 patients with oral candidosis were selected for the study group,
diagnose confirmed by clinical and laboratory examination (cultivation on Sabouraud medium
and gram microscopy), among them 12 women (60%) and 8 men (40%) of different age, most of
the affected persons of 30-49 years old (50%). All patients from the study group have been
subject of a complex treatment: etiotrop, imuno-stimulating, hygienic and dietetic.
Results. In the study group, oral candidosis was found together with concomitant illness:
endocrine (40%), cardiovascular (25%), gastrointestinal (45%), respiratory (30%). There was
established a relation between candidosis and certain periods of the year, with an increased
frequency during winter-spring season (25-40%), explained by respiratory pathways illness and
antibiotic therapy treatment. Locally, the lesions were found on tongue, palatal and angular
mucosa. Treatment efficiency was of 90%, number confirmed by clinical examination and
laboratory tests.
Conclusions. The efficiency of oral candidosis treatment is based on a complex therapeutic
approach, focused on etiology and interruption in the pathogenic chain, rebalancing the immune
capacities, prophylaxis of relapses and prolonging the remission period.
Description:
Department of odontology,
periodontology and pathology,
Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldov
