dc.contributor.author |
Donici, Elena |
|
dc.date.accessioned |
2020-07-03T17:26:17Z |
|
dc.date.available |
2020-07-03T17:26:17Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
DONICI, Elena. The evaluation of some techniques of thermal analysis at the preformulation stage of combined drugs. In: MedEspera: the 7th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2018, p. 277. |
en_US |
dc.identifier.uri |
https://medespera.asr.md/wp-content/uploads/Abastract-Book-2018.pdf |
|
dc.identifier.uri |
http://repository.usmf.md/handle/20.500.12710/10904 |
|
dc.description |
Department of Pharmaceutical and
toxicological chemistry,
Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova |
en_US |
dc.description.abstract |
Introduction. Thermal analysis includes several analysis techniques, which measure an
analytical signal of the sample at a certain temperature. The analysis is based on
thermogravimetric curves. The instrument used in thermal analysis consists of a microbalance
surrounded by a electrically heated furnace equipped with a thermocouple to monitor the
temperature.
Aim of the study. is to assess the use of of thermo-gravimetric and differential scanning
calorimetry methods at the preformulation stage of combined drugs.
Materials and methods. Electronic databases: Medline, Cochrane, Embase and Springer. Also,
the search was conducted by using printed, pharmaceutical and chemical journals. It was
analyzed 150 bibliographic sources.
Results. In most of the researches (45%), thermogravimetric analysis was used in order to
determine the decomposition temperature of the individual active substances and also from the
mixtures of active substances with excipients or with other active substances. Also, most
frequently (53.3%), thermogravimetric analysis has been combined with other techniques such
as: differential scanning calorimetry. Less researches (1.7%) applied thermogravimetric method
to determine water content and volatile substances.
Conclusions. Thermogravimetry and differential scanning calorimetry are physicochemicalmethods
which are widely used for compatibility research of active substances and
excipients at the preformulation stage of drugs. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
MedEspera |
en_US |
dc.subject |
thermogravimetry |
en_US |
dc.subject |
preformulation |
en_US |
dc.subject |
combined drugs |
en_US |
dc.title |
The evaluation of some techniques of thermal analysis at the preformulation stage of combined drugs |
en_US |
dc.type |
Article |
en_US |