Abstract:
Introduction. Parkinson disease is a progressive disorder of the nervous system. The disorder
affects several regions of the brain, especially an area called the substantia nigra that controls
balance and movement. Although the etiology of Parkinson disease is still unclear, most cases
are hypothesized to be due to a combination of genetic- 10% and environmental factors.
Aim of the study. Evaluation of the genetic and environmental factors in etiopathogenesis of
Parkinson's disease. Study of the molecular mechanisms involved in the etiology of PD;
Evaluation of the major genes for higher risk of PD; Estimating the role of environmental and
genetic factors in the onset, development and prognosis PD; Prospects survey prevention and
treatment of PD.
Materials and methods. Scientific articles review.
Results. A total of 18 loci in various genes have now been proposed for PD. Mutations within 6
of these loci (SNCA, LRRK2, PRKN, DJ1, PINK1, and ATP 13A2) are well-validated causes of
familial parkinsonism. Inheritance is autosomal dominant for SNCA and LRRK2. Inheritance is
autosomal recessive for PRKN, DJ1, PINK1, and ATP13A2. Stem cell therapy for Parkinson’s
disease (Embryonic Stem Cells/ induced Pluripotent Stem Cells (iPSCs) that are adult cells (e.g.
skin cells)) is a potential treatment for PD, because the most significant neuronal degeneration is
site and type specific (ie, dopaminergic); the target area is well defined (ie, striatum);
postsynaptic receptors are relatively intact. Gene therapy has distinct theoretical advantages over
conventional treatment for Parkinson's disease as it might preserve or restore dopaminergic
neurons through the use of growth factors or alternatively increase the availability of enzymes
required for dopamine synthesis.
Conclusions. Neurodegeneration in PD is due to three interrelated molecular mechanisms:
changes oxiative, mitochondrial dysfunction and degradation of proteins affected. Major genes
are involved in Parkinson disease: SNCA, LRRK2, PRKN, DJ1, PINK1, ATP13A2, GBA.
Environmental and genetic factors play an important role in the onset, development and
prognosis BP, and they can vary from one patient to another and will depend on the root cause.
Perspentivele in prevention and treatment of PD are presimptomatic screening and gene therapy.
