A rare case of multiple myeloma in a patient with an unresponsive to chemo-and radiotherapy frontoparietal gygantic plasmacytoma

Abstract

Introduction: Multiple myeloma is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies. In multiple myeloma, collections of abnormal plasma cells accumulate in the bone marrow, where they interfere with the production of normal blood cells. Most cases of multiple myeloma also feature the production of a paraprotein - an abnormal antibody which can cause bone lesions and hypercalcemia. Plasmacytoma refers to a tumour consisting of abnormal plasma cells that grows within the soft tissue or bony skeleton in the context of multiple myeloma disease. Objective: We will present the case of a 56 years old female patient admitted in the Medical Clinic I - Department of Hematology of Targu Mures, suffering from a rare hematological cancer - multiple myeloma of which onset was the appearance of a solitary extramedullary gigantic frontoparietal plasmacytoma which also did not responded at all to chemo-and radiotherapy treatment still increasing its size. Clinical case: We monitored the patient over a period of 13 months and we will display the evolution chronologically.Conclusions: Usually radiotherapy provides excellent local and regional control of plasmacytomas, but in our case it had no positive effect. The patient is having an evolution which leads to an continue worsening without obtaining remission, therefore the long-term prognosis is reserved while the medium one is favorable.