Recurrent laryngeal papillomatosis in children

Abstract

Introduction: Assessing the dynamics and structure of recurrent laryngeal papillomatosis common for children from Moldova compared to the results obtained in this research with general ones published in the sources specific to the problem.Metdhods and Materials Historical: how the phenomena evolved in time during 1981-2013 in Republic of Moldova; Chronological series: calculation of all comparable homogeneous values, that characterize the modification of a certain phenomena in a certain period of time; Statistical Methods: quantitative and qualitative analysis of all data that were collected during the research. Discussion Results: 1. Children’s recurrent laryngeal papillomatosis has a incidence from 0.2 to 0.7 for 100,000 children in Republic of Moldova compared to: Norway: 0.10-0.25 for 100,000 children, Sweden: 0.2- 0.7 for 100,000 children, Denmark: 0,362 for 100,000 children, Canada: 1,11 for 100,000 children; 2. Average age to diagnose the disease is 4,4 years and is specific for both genders (masculine: femenin 1,2:1) in Republic of Moldova; 3. Rate of tracheotomy is between 1,8% and 64%, 30 average % is specific for children in Republic of Moldova Conclusions: Our cohort of patients is similar to other cohorts regarding the sex distribution and age of onset. Clinical evolution of this disease is various. Some patients have early spontaneous remission; others, on the other hand, suffer from frequent and inexorable relapses lasting over decades to overlapping chronic complications that scar stenosis of the larynx with the imposition of a cannula tracheostomy or malignant transformation. Laryngeal papillomatosis has a huge impact on the life of children that are affected.