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Correlation between trans fatty acids and cardiovascular pathology

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dc.contributor.author Istratii, Eugenia
dc.date.accessioned 2020-07-06T07:32:24Z
dc.date.available 2020-07-06T07:32:24Z
dc.date.issued 2018
dc.identifier.citation ISTRATII, Eugenia. Correlation between trans fatty acids and cardiovascular pathology. In: MedEspera: the 7th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2018, p. 198-199. en_US
dc.identifier.uri https://medespera.asr.md/wp-content/uploads/Abastract-Book-2018.pdf
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/10975
dc.description Department of Biochemistry and Clinical Biochemistry, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova en_US
dc.description.abstract Introduction. Current studies reveal the harmful effect of trans fatty acids on cardiovascular health. Each additional gram of trans fatty acids increases the risk of myocardial infarction by approximately 5%. trans fatty acids, in principle isomers (18: 1) have two origins: natural trans fatty acids derived from the bio hydrogenation of ruminant unsaturated fatty acids and industrial trans fatty acids derived from the industrial hydrogenation of unsaturated vegetable oils. Aim of the study. Elucidating the role of trans fatty acids in the mechanisms of production and evolution of cardiovascular diseases by comparing the two origins of trans fatty acids and other types of trans fatty acids. Materials and methods. In order to achieve the proposed goal, the publications from the specialized journals of the PubMed, Medline and Hinari electronic libraries have been used, based on a series of observational studies, system reviews and experiments on diet. The aim of majority of observational studies was the coronary heart disease often in the form of myocardial infarction or fatal or non-fatal stroke. Results. Following the summary of the studies we have concluded: the consumption of industrial trans fatty acids can reduce high density lipoprotein (HDL) concentrations, while increasing at the same time low density lipoprotein (LDL) and very low density lipoprotein (VLDL) concentrations. As a result, increased cholesterol / HDL ratio, which is able to raise lipoprotein concentrations (a), a risk factor for cardiovascular disease, has been detected. Increased inflammation markers, including TNF-alpha, C-reactive protein and interleukin-6, associated with endothelial dysfunction markers that contribute to atherosclerosis and hypertension, have been reported. Conclusions. Epidemiological studies and meta-analyzes of the latest clinical studies have shown that trans fatty acids from industrial sources are responsible for the damage caused in particular by the lipid profile, whereas the trans fatty acids from natural sources have a reduced effect on the lipid profile and other risk factors cardiovascular. However, the mechanisms, the origin of these variations according to isomers is not yet well known and need further studies. en_US
dc.language.iso en en_US
dc.publisher MedEspera en_US
dc.subject fatty en_US
dc.subject acids en_US
dc.subject cardiovascular en_US
dc.subject VLDL en_US
dc.title Correlation between trans fatty acids and cardiovascular pathology en_US
dc.type Article en_US


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  • MedEspera 2018
    The 7th International Medical Congress for Students and Young Doctors, May 3-5, 2018

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