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dc.contributor.author Malii (Astifeni), Galina
dc.contributor.author Vîslouh, O.
dc.date.accessioned 2020-07-07T08:28:25Z
dc.date.available 2020-07-07T08:28:25Z
dc.date.issued 2018
dc.identifier.citation MALII (Astifeni), Galina, VÎSLOUH, O. Comparison of Fluconazol capsules dissolution profiles. In: MedEspera: the 7th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2018, p. 278. en_US
dc.identifier.uri https://medespera.asr.md/wp-content/uploads/Abastract-Book-2018.pdf
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/11064
dc.description Department of Pharmaceutical and Toxicological Chemistry, The Scientific Center of drug, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova en_US
dc.description.abstract Introduction. The dissolution test is the most used physico- chemical test in the evaluation of the quality of the medicinal product to assess the in vitro-in vivo correlation. In the development of drug formulation, is it used to select optimal composition, study of stability and physicochemical parameters required in the technological process, and in quality control for verifying the reproducibility of in vitro release of series launched on the pharmaceutical market. Aim of the study. is to investigate the dissolution profile of Fluconazole-RNP 50 mg capsules compared to another recognized manufacturer (Mycosyst 50 mg Gedeon Richter Ltd. (Hungary) capsules. Materials and methods. "Shimadzu" HPLC Chromatograph with RID-10A Detector; electronic analytical balance; pH meter Consort C861; Fuconazole-RNP and Mycosyst Gedeon Richter capsules; acetonitrile; methanol. Results. The dissolution test demonstrated the similarity of the dissolution profiles of the compared products. Conclusions. All media used to compare the dissolution profiles of fluconazole capsules in the dissolution test show that the similarity factor (f2) is at least 50, which demonstrates the similarity of the fluconazole-RNP bioavailability compared to Mycosyst. en_US
dc.language.iso en en_US
dc.publisher MedEspera en_US
dc.subject dissolution test en_US
dc.subject bioavailability en_US
dc.subject fluconazole en_US
dc.subject Mycosyst en_US
dc.subject similarity en_US
dc.title Comparison of Fluconazol capsules dissolution profiles en_US
dc.type Article en_US


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  • MedEspera 2018
    The 7th International Medical Congress for Students and Young Doctors, May 3-5, 2018

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