Abstract:
Introduction. Circadian rhythm is one of the most important mechanisms in human body, which
coordinates biological rhythms with the environmental changes in the day-night cycle. People
are diurnal species, so we are used to work during the day and to sleep during the night. Sleep
and Circadian Rhythm Disruption (SCRD) occurs when natural circadian rhythms are pushed out
of synchronization, for example in shift work.
Aim of the study. Define the mechanistic links between sleep and circadian rhythm disruption
and hyperglycemia. Apply this knowledge for the development of evidence-based clinical
interventions. Transfer this knowledge to the broader community, patients and caregivers.
Materials and methods. This study was based on physiological, biological and laboratory
investigations, that were used to determine respiratory frequency, heartbeat frequency, muscular
strength, tremor, blood and liver tests.
Results. It was established that shift-workers have increased level of glucose in blood.
Conclusions. Sleep and Circadian Rhythm Disruption in shift work leads to hyperglycemia, that
can induce diabetes mellitus.
