Clinico-evolutional particularities of the metabolicsyndrome in gout

Abstract

Introduction: The prevalence of gout has increased in recent decades in most of the countries, but the growth of gout in the developed countries has been linked to changing lifestyles and refuse to traditional diet. Metabolic syndrome is Associated with many diseases, some of them have evolutionally grievous potential. It was found that metabolic syndrome exists in presence of gout. It is very important to know the risk factors, to take some measures for the disease prevention. Purpose: to study clinical-evolutional particularities of the metabolic syndrome in gout and to determinate risk factors for such patients. Materials and Methods: 50 patients were analyzed according to the gout classification criteria. Patients were hospitalized in Rheumatology and Arthrology Departments of Republican Clinical Hospital. Patients average age was 48.2, and the average duration of disease - 5.1 years. Results: It was found that 50 (100%) patients had arthritis and 41 (82%) patients had metabolic syndrome. The following risk factors were identified: overweight and obesity in 41 (82%) patients, high blood pressure and drugs taking in 32 (64%) patients, alcohol - 29 (58%) and diet rich in meat - 26 ( 52%). Conclusion: the gout diagnosis must be accompanied by thorough assessment of the metabolic syndrome components: high blood pressure, insulin resistance, dyslipidemia, abdominal obesity. It was determined that gout represents independent cardiovascular risk factor, which increase the risk of heart attack. Hypocalorical diet at patients who have dyslipidemia do not decrease only serum lipid level, butalso uric acid level; by increasing renal excretion of urate. Thus, change of lifestyle have a significant effect on the disease evolution, recommending to reduce purine-rich foods and alcohol consumption.