dc.contributor.author |
Pîrțu, Ana-Iulia |
|
dc.date.accessioned |
2020-07-08T07:19:09Z |
|
dc.date.available |
2020-07-08T07:19:09Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
PÎRȚU, Ana-Iulia. Role of matrix metalloproteinases in angiogenesis and progression of atherosclerotic plaque. In: MedEspera: the 7th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2018, p. 176-177. |
en_US |
dc.identifier.uri |
https://medespera.asr.md/wp-content/uploads/Abastract-Book-2018.pdf |
|
dc.identifier.uri |
http://repository.usmf.md/handle/20.500.12710/11137 |
|
dc.description |
Department of Morphopathology,
Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova |
en_US |
dc.description.abstract |
Introduction. Atherosclerosis is a chronic disease characterized by multifocal structural
alterations of the vascular wall of medium and large arteries, leading to the accumulation of
cholesterol and continuous inflammation. Inflammatory angiogenesis in atherosclerotic lesions
plays a major role in plaque progression and instability.
Aim of the study. The review examines the role of the MMPs in plaque angiogenesis,
destabilization, and its relation to inflammation.
Materials and methods. Informational support for the development of this review is based on
current international journals, including more than 50 references in English and Russian
languages.
Results. It is firmly established that extracellular proteolysis mediated by MMPs is an absolute
requirement for angiogenesis. MMPs released by inflammatory cells, are implicated in the
sprouting phase, including basement membrane degradation and cell migration/ECM invasion.
The neovascularization prevents cellular death due to better supply of O2 and nutrients. But
simultaneously allows lipid core expansion, leukocyte afflux, plaque growth and destabilization
due to the compromised structural integrity of imature vessels (discontinuous basement
membrane, low number of tight junctions between the ECs, lack in pericyte coverage)highly
susceptible to intraplaque hemorrhage. In atherosclerotic plaques, MMPs not only induce the sprouting of neovessels but also can provoke net destruction of collagen in the shoulder regions
of fibro-atheromas and thus contribute to the weakening of the fibrous cap and precipitate
transition to an unstable lesion, plaque rupture, leading to myocardial infarctions or strokes.
Furthermore, specific MMPs have been shown to enhance angiogenesis by releasing ECMbound
angiogenic growth factors.
Conclusions. By providing pathological angiogenesis MMPs may induce plaque growth,
maintenance or destabilizing of the atherosclerotic plaque. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
MedEspera |
en_US |
dc.subject |
atherosclerosis |
en_US |
dc.subject |
angiogenesis |
en_US |
dc.subject |
matrix metalloproteinases |
en_US |
dc.title |
Role of matrix metalloproteinases in angiogenesis and progression of atherosclerotic plaque |
en_US |
dc.type |
Article |
en_US |