Healing of trophic ulcers with bioplastic collagen material collost

Abstract

Introduction: COLLOSTтм is sterile bioplastic collagen material with preserved fibrous structure which activates regeneration of affected tissues. It is based on bovine collagen type I, which is close to human collagen by its composition and structure. The aim of the study was to assess the efficacy of COLLOSTтм in treatment of the trophic ulcers, which have been refractory to previous treatment modalities. Material and methods: In our study there were included 9 patients who had trophic ulcers in lower limbs with reduced or no response to standard treatment during a long time periods: from 1 month to 30 years. The etiology of trophic ulcer was diabetes mellitus (5 patients), osteomyelitis (1) and postthrombotic syndrome (3). In 5 patients the wounds were closely covered by COLLOSTтм in form of perforated membranes. In 4 patients the treatment was performed using both COLLOSTтм 7% gel and perforated membrane. Discussion results: All patients showed good response to the treatment. After the 2nd day of treatment the patients reported no pain. The edema and size of the wounds were reduced in the period from 7 to 14 days. The efficiency of COLLOSTтм is determined by the following factors: high penetration of the cells; good adhesion to the wound; providing of tissue regeneration; no inducing of antigenic reaction, and has low risk in transition of viral or microbial infections.Conclusions: Initial experience of using COLLOSTтм in local treatment of trophic ulcers indicates on perspectives of its application.