Evaluation of the varicose veins as a surrogate marker of the thrombophilic disorders in pregnancy

Abstract

Introduction: A successful pregnancy outcome requires an efficient utero-placental circulation. It may be compromised by hemostasis disorders Associated with a prothrombotic state, such as thrombophilia. Thrombophilia includes a large spectrum of disorders that have been assigned topregnancy complications as: preeclampsia, recurrent fetal loss and other. Also, recent studies showed higher incidence of thrombophilia in people with varicose veins, suggesting an association between these diseases. As the screening of thrombophilia is expensive and the diagnosis is frequently established late, we aimed to evaluate in this study the relevance of using the varicose veins as an indirect marker of thrombophilia that could lead to an earlier diagnosis, reducing costs and morbidity. Materials and methods: The case control study was based on the data of 140 pregnant women admitted in the Department of Obstetrics of The Institute of Mother and Child, in the period of 2011- 2014. They were evaluated from the perspective of their obstetrical complications suggestive for thrombophilia.Conclusions: Women with varicose veins were more prone to develop thrombophilia Associated complications during pregnancy. This leads us to the idea of using the varicose veins as an early indicator /surrogate marker of a possible thrombophilic disorder, helping to establish the diagnosis and begin prophylaxis or an adequate treatment faster.