Abstract:
Introduction. One of the major concerns of modern medicine is the use of new, long-acting
antihypertensive drugs. Numerous studies have confirmed the importance of correct treatment of
hypertension to reduce cardiovascular morbidity and mortality. Physicians now have a choice of
a wide range of antihypertensive drugs with numerous evidence of their efficacy, but which often
cause side effects limiting their widespread use. Benzituron or S-benzylisothiourea chloride is
referred to a new range of hypotensive substances, isothiourea derivatives, able to reduce and to
stabilize the level of the arterial blood pressure. The solution of the benzituron, in dosage of 2
mg/kg shows a noticeable hypotensive and antihypertensive action, with duration from 4 to 5
hours.
Aim of the study. To evaluate the effect of benzituron on blood pressure and heart rate on the
background of adrenergic receptor blockade with propranolol.
Materials and methods. The experiments were performed on 14 cats 2-4 kg body weight
anesthetized with 30% urethane solution (500 mg/kg) and chloralose (50 mg/kg) administered
intraperitoneally, followed by blood pressure and heart rate monitoring at different intervals of
time.
Results. The 0.2 mg/kg propranolol solution was administered intravenously with effect
assessment at 2 and 5 minutes, followed by 5 minutes intravenous administration of isoprenaline
solution 0.005 mg/kg, then 2 mg/kg benzituron dissolved in 1,5 ml physiological saline solution
with effect recording at certain time intervals. Isoprenaline was injected to demonstrate β-
adrenoceptor blockade by propranolol. Subsequent intravenous injection of benzituron resulted
in a decrease in blood pressure at the 60th minute.
Conclusions. Benzituron in the dose of 2 mg/kg exerts hypotensive effect on the background of
blockade of β-adrenoreceptors.
