Ultradian biorhythm’s influence in cell population. Applicative aspects

Abstract

Introduction: Ultradian biorhythms represent biological rhythms which last between 20 and 90 minutes. They were discovered in 50s of the last century and approved by using several techniques of quantitative and qualitative analyzes which demonstrated than that ultradian biorhythms were characteristic only for some segregated cells, and later there was discovered their influence in regulation and synchronization of adjacent cell population, also their importance in entire organism homeostasis maintaining. This research aims to evaluate and categorize the most important aspects of this approaches.

Materials and methods: In order to find answers to the proposed questions, a bioinformatic study is needed, by using PubMed and Link Springer data base which will be analyzed and structured in the following way.

Discussions and results: it was discovered that u. biorhythms have more than 20 impacts over cell functions and properties, such as ATP synthesis, nucleic acids synthesis, synthesis of proteins, cell activity, protein secretion, cell respiration, the amount of cAMP, and also sometimes u. biorhythms may influence even the weigh and the size of the cell. Ultradian biorhhythms were identified not only at human, but also at the rest of mammals, crustaceans, molluscs, protozoa, bacteria and other single-celled organisms. During the study it was determined that this biorhythms are not anything else than the result of auto-organization of cell population’s oscillations. Actually, exists the idea that this biorhythms are synchronized by the gangliosides, this was confirmed by several experiments in vitro, where in the intercellular space of some cell populations was introduced gangliosides, and in this way was discovered that they were responsible for different processes, the most obvious one was the oscillations during proteins’ synthesis. More recent and more complex studies show us a more adaptable model regarding the synchronization of different cell populations, in this way the biorhythms control occurs as fallow: endogenously ( interstitial fluid ) which involves the following reactions: gangliosides, attach to specific receptors and release Ca2 + depots, calcium activates protein kinase, so the phosphorylation of specific proteins occurs and thus sets the stage of biorhythms of synthesis; Exogenously ( blood) in the same way, the only difference is that protein kinase activated by cAMP which is activated by the adenylate cyclase, the last one (adenylate cyclase) is activated by adrenaline, serotonin, melatonin, etc. In this context, it was possible to insight and later to confirm by experimental studies that cell proliferation depends not only on circadian rhythms but also on those ultradian ones, in this way they having an applicable aspect in regenerations, ontogenesis and oncological diseases. Other practical aspects which may be named: heart work, the efficiency of catecholamine receptors and their secretion, the entire system of organs, intercellular communications, cellular function. Another aspect, also very important, is that the process of aging may be Associated with a imbalance of intercellular synchronization, therefore, imbalance at the level of different ultradian rhythms. Researched phenomenon has important application in several clinical aspects: 1 ) In this way it adjusts the functions of the entire body; 2) The mechanism affects the ability of the body to work well with a determined frequency; 3) The quantitative difference of some substances at different periods of time, is important in the effectiveness of drugs introduced in different phases of ultradian cycles; 4 ) The perspective to compensate aging effects by introducing certain substances in the intercellular space.5) Better understanding of different organ systems functionality and the possibility of diagnosis according to the case.

Conclusions: Ultradian biorhytms are not just a trend, and due to high-technologies developement, they may be used during diagnosis and during the treatement and planification of therapeutic maneuvers as well. It rests to elucidate, argumentate optimal, corect, economical and affordable methods of personalized determination of these rhythms.