Histopathological and clinical investigation on the influence of intracanal medication in the treatment of chronic periodontitis

Abstract

Introduction: One of the major tasks in the treatment of chronic apical periodontitis is regeneration of pathologically changed periapical tissues.This goal might be achieved by means of different remedies introduced into periapical tissues, stimulating the regeneration of damaged tissues.

Aim: This work investigates the efficiency of a temporary paste in the treatment of chronic apical periodontitis.The paste contains: Metronidazole, Enterosgel,Alflutop.

Materials and method: Investigation included: experiments on rats and experimental group ( 30 teeth presenting chronic apical periodontitis ). The drug Collapan was used as a comparative remedy.

Result: In the histological specimens of the mandible bone defects of the 6 th -7 th groups rats (filled with Collapan), bone defect was significantly similar to the condition of bone tissue of the 4 th and 5 th groups rats (filled with proposed composition). Signs of reparation expressed in the formation of big number of new form blood vessels, active osteoblaste, connective tissues formation were closely attached to the bone tissue. In the 30 cases under study, the treated teeth caused no pain, assured a good mastication and the adjiacent mucous membrane evidenced no pathological modification.

Conclution: Our histological investigation have proved the osteoregenerative abilities of the proposed medicamental composition, similar to those of the material used as a control Collapan. This affords grounds to consider that the proposed medicamental composition possesses significants clinical efficiency for usage in the treatment of chronic apical periodontitis stimulation regeneration of damaged periapical tissues.