Abstract:
Introduction:
Micro-RNAs (miRNAs) were defined as small endogenous
non-coding RNAs consisting of 18-24 nucleotides,
responsible for the gene expression and involved in many
cellular processes (Figure 1). The expression of the
enzyme plasminogen activator inhibitor-1 (PAI-1), the
main modulator of thrombosis, fibrinolysis,
inflammation, angiogenesis and atherogenesis, encoded
by SERPINE-1 locus, has been recently discovered to be
inhibited or stimulated by different miRNAs [1]. The
exact role of miRNA as biomarkers and treatment targets
of fibrinolysis disorders remains the subject of
continuous research.
Purpose:
To study the literature data regarding the
role of miRNA in the processes of
fibrinolysis for identifying the possible
diagnostic and therapeutic strategies.
Material and methods:
There were analyzed: Wiley Online library,
Crossref, Google Scholar databases, using the
combination of the terms “miRNA in
fibrinolysis”, “regulation of plasminogen
activator inhibitor-1” in the articles published
between years 2012-2020.
Conclusions:
A number of miRNAs were suggested both as potential biomarkers
for the diagnosis of thrombotic disorders, and as a treatment
perspective for venous thrombosis.
Description:
“Nicolae Testemițanu” State University of Medicine and Pharmacy,
Chair of biochemistry and clinical biochemistry, Chisinau, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltare