The role of micro-RNA in fibrinolysis

Abstract

Introduction: Micro-RNAs (miRNAs) were defined as small endogenous non-coding RNAs consisting of 18-24 nucleotides, responsible for the gene expression and involved in many cellular processes (Figure 1). The expression of the enzyme plasminogen activator inhibitor-1 (PAI-1), the main modulator of thrombosis, fibrinolysis, inflammation, angiogenesis and atherogenesis, encoded by SERPINE-1 locus, has been recently discovered to be inhibited or stimulated by different miRNAs [1]. The exact role of miRNA as biomarkers and treatment targets of fibrinolysis disorders remains the subject of continuous research. Purpose: To study the literature data regarding the role of miRNA in the processes of fibrinolysis for identifying the possible diagnostic and therapeutic strategies. Material and methods: There were analyzed: Wiley Online library, Crossref, Google Scholar databases, using the combination of the terms “miRNA in fibrinolysis”, “regulation of plasminogen activator inhibitor-1” in the articles published between years 2012-2020. Conclusions: A number of miRNAs were suggested both as potential biomarkers for the diagnosis of thrombotic disorders, and as a treatment perspective for venous thrombosis.