Abstract:
Introduction:
MiRNA is involved in the evolution of heart
diseases through regulation of gene expression
with the development of pathological phenotype.
Deviations of miRNA expression were
described in various cardiovascular conditions,
including cardiac hypertrophy, coronary heart
disease, myocardial infarction.
Purpose:
Studying the types, location, role of
intracellular miRNA and blood microparticles,
as well as identifying their correlations with
the development of cardiac pathological
processes.
M aterial and methods
The references in the international scientific
literature, such as the databases of the PubMed
and Springer Link electronic libraries were
examined.
Results
MiRNAs are found in circulating vesicles and serve as potential
biomarkers for various cardiovascular pathologies. The most expressed
miRNAs in the heart diseases are miR-1, miR-133, miR-208 and
miR-499, such as follows: [tabel]. Increased miRNA expression is reduced by the administration of
chemical competitive inhibitors (antagomiR) specific to these molecules,
that prevent the binding of a desired situs on a mRNA molecule.
Conclusions:
MiRNA regulates gene expression in cells and ensures itercellular
communication. Circulating miRNAs are used as biomarkers in the
diagnosis and prognosis of cardiovascular pathologies.
Description:
State University of Medicine and Pharmacy „Nicolae Testemițanu”
Department of Biochemistry and Clinical Biochemistry, Chișinău, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltare