Micro-RNA (miRNA) aspects in cardiovascular diseases

Abstract

Introduction: MiRNA is involved in the evolution of heart diseases through regulation of gene expression with the development of pathological phenotype. Deviations of miRNA expression were described in various cardiovascular conditions, including cardiac hypertrophy, coronary heart disease, myocardial infarction. Purpose: Studying the types, location, role of intracellular miRNA and blood microparticles, as well as identifying their correlations with the development of cardiac pathological processes. M aterial and methods The references in the international scientific literature, such as the databases of the PubMed and Springer Link electronic libraries were examined. Results MiRNAs are found in circulating vesicles and serve as potential biomarkers for various cardiovascular pathologies. The most expressed miRNAs in the heart diseases are miR-1, miR-133, miR-208 and miR-499, such as follows: [tabel]. Increased miRNA expression is reduced by the administration of chemical competitive inhibitors (antagomiR) specific to these molecules, that prevent the binding of a desired situs on a mRNA molecule. Conclusions: MiRNA regulates gene expression in cells and ensures itercellular communication. Circulating miRNAs are used as biomarkers in the diagnosis and prognosis of cardiovascular pathologies.