Abstract:
Introduction:
Cardiovascular disease (CVD) is the leading cause of death and
disability worldwide [1]. The onset of the cardiovascular disease
(CVD) anticipates the symptoms. Biomarkers play a critical role in
the definition, prognostication, and decision-making regarding the
management of cardiovascular events [2]. In adulthood a number of
inflammatory biomarkers are associated with the increased
cardiovascular risk, however, these biomarkers are insufficiently
studied in the young population.
Purpose:
To examine the high-sensibility C-reactive protein and IL-6
inflammatory biomarkers in young people.
Material and methods:
A cross-cutting study was carried out on 88 young subjects,
apparently healthy.
Material and methods:
The concentration of the inflammatory biomarkers in blood was
determined: the high-sensitivity C-reactive protein (hsCRP) by the
enzyme-linked immunosorbent assay and IL-6 by the lateximmunoturbidimetry
method.
Results:
The concentration of hsCRP ranged from 0.01 to 11.10 mg / l, averaging
0.56 ± 0.16 mg / l, with some sex differences: 0.61 ± 0, 14 mg / l in males
versus 0.54 ± 0.21 (p <0.05) in females. The IL-6 value ranged from 1.12
to 5.60 (2.23 ± 0.07) pg / ml, the results recorded in male subjects,
statistically (2.34 ± 0.17 pg / ml) were significantly higher than in women
(2.19 ± 0.07 pg / ml) (p <0.05). An increasing trend of IL-6 and hsCRP
with age was registered, however, the differences between age groups ≤
20 and> 20 years old were insignificant (p> 0.05).
Conclusions:
The inflammatory biomarkers have an increasing tendency in
concentration with age, being more expressed among men. However,
longitudinal studies are needed to assess the role of the studied
biomarkers and their value in predicting the cardiovascular risk.
Description:
Department of Family Medicine, State University of Medicine and Pharmacy "Nicolae Testemitanu", Chișinău, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltare