Biomarkers of inflammation - cardiovascular risk predictors in young people

Abstract

Introduction: Cardiovascular disease (CVD) is the leading cause of death and disability worldwide [1]. The onset of the cardiovascular disease (CVD) anticipates the symptoms. Biomarkers play a critical role in the definition, prognostication, and decision-making regarding the management of cardiovascular events [2]. In adulthood a number of inflammatory biomarkers are associated with the increased cardiovascular risk, however, these biomarkers are insufficiently studied in the young population. Purpose: To examine the high-sensibility C-reactive protein and IL-6 inflammatory biomarkers in young people. Material and methods: A cross-cutting study was carried out on 88 young subjects, apparently healthy. Material and methods: The concentration of the inflammatory biomarkers in blood was determined: the high-sensitivity C-reactive protein (hsCRP) by the enzyme-linked immunosorbent assay and IL-6 by the lateximmunoturbidimetry method. Results: The concentration of hsCRP ranged from 0.01 to 11.10 mg / l, averaging 0.56 ± 0.16 mg / l, with some sex differences: 0.61 ± 0, 14 mg / l in males versus 0.54 ± 0.21 (p <0.05) in females. The IL-6 value ranged from 1.12 to 5.60 (2.23 ± 0.07) pg / ml, the results recorded in male subjects, statistically (2.34 ± 0.17 pg / ml) were significantly higher than in women (2.19 ± 0.07 pg / ml) (p <0.05). An increasing trend of IL-6 and hsCRP with age was registered, however, the differences between age groups ≤ 20 and> 20 years old were insignificant (p> 0.05). Conclusions: The inflammatory biomarkers have an increasing tendency in concentration with age, being more expressed among men. However, longitudinal studies are needed to assess the role of the studied biomarkers and their value in predicting the cardiovascular risk.