Abstract:
Background. As a consequence of the chronic inflammatory process, children with rheumatic
conditions can present with both - variable degree of joint pain and limitation of the range of motion,
the last one, sometimes being followed by ankylosis. Objective of the study. Assessment of serum level
of 25-OH vitamin D in children with rheumatic conditions and glucocorticoteroid treatment
(GCS). Material and Method. Twenty four (24) children with confirmed rheumatic conditions treated
with systemic glucocorticosteroids were included in the study. All the patients received GCS, with an
average duration of 28,02±27,74 months. The assessment of 25-OH vitamin D was done through
immunoenzymatic assay. Results. The average value of total serum 25-OH vitamin D in children
included in the study was 14,57±5,66 ng/ml. Suboptimal level was detected in 51,72% of children (range
20-50 ng/ml). Importantly, in children with juvenile idiopathic arthritis average level of vitamin D was
135±63,87 ng/ml. Patients with connective tissue diseases had an average level of total serum vitamin
D of 12,44 ±5,25 ng/ml. Conclusion. These findings could serve as a base for recommendations aiming
the prevention of vitamin D deficiency in patients with chronic rheumatic conditions. Introducere. Ca urmare a procesului inflamator cronic, copiii cu maladii reumatice prezintă sindrom
algic articular de intensitate variată, limitarea mobilității pe termen variabil, uneori până la anchilozare
articulară. Vitamina D poate avea un rol important în patogenia maladiilor autoimune. Scopul
lucrării. Evaluarea titrului 25-OH vitamina D totală în ser, la copii cu maladii reumatice cronice, cu
tratament cronic cu glucocorticosteroizi (GCS). Material și Metode. În studiu au fost incluși 24 copii
cu maladii reumatice confirmate, care au fost supuși tratamentului cu glucocorticosteroizi. Media vârstei
copiilor din studiu a fost 144,83±61,08 luni. Toți copiii au primit tratament cu GCS, durata medie de
administrare fiind 28,02±27,74 luni. 25-OH vitamina D totală a fost determinată prin metoda
imunoenzimatică. Rezultate. Rezultatele obținute ar putea sta la baza realizării unor recomandări
menite să prevină deficitul de vitamina D la copiii cu maladii cronice reumatice. Concluzii. Rezultatele
obținute ar putea sta la baza realizării unor recomandări, menite să prevină deficitul de vitamina D la
copiii cu maladii cronice reumatice.
