Evaluation of bone metabolism status in children with rheumatic diseases through the assessment of the total serum 25-OH vitamin D

Abstract

Background. As a consequence of the chronic inflammatory process, children with rheumatic conditions can present with both - variable degree of joint pain and limitation of the range of motion, the last one, sometimes being followed by ankylosis. Objective of the study. Assessment of serum level of 25-OH vitamin D in children with rheumatic conditions and glucocorticoteroid treatment (GCS). Material and Method. Twenty four (24) children with confirmed rheumatic conditions treated with systemic glucocorticosteroids were included in the study. All the patients received GCS, with an average duration of 28,02±27,74 months. The assessment of 25-OH vitamin D was done through immunoenzymatic assay. Results. The average value of total serum 25-OH vitamin D in children included in the study was 14,57±5,66 ng/ml. Suboptimal level was detected in 51,72% of children (range 20-50 ng/ml). Importantly, in children with juvenile idiopathic arthritis average level of vitamin D was 135±63,87 ng/ml. Patients with connective tissue diseases had an average level of total serum vitamin D of 12,44 ±5,25 ng/ml. Conclusion. These findings could serve as a base for recommendations aiming the prevention of vitamin D deficiency in patients with chronic rheumatic conditions. Introducere. Ca urmare a procesului inflamator cronic, copiii cu maladii reumatice prezintă sindrom algic articular de intensitate variată, limitarea mobilității pe termen variabil, uneori până la anchilozare articulară. Vitamina D poate avea un rol important în patogenia maladiilor autoimune. Scopul lucrării. Evaluarea titrului 25-OH vitamina D totală în ser, la copii cu maladii reumatice cronice, cu tratament cronic cu glucocorticosteroizi (GCS). Material și Metode. În studiu au fost incluși 24 copii cu maladii reumatice confirmate, care au fost supuși tratamentului cu glucocorticosteroizi. Media vârstei copiilor din studiu a fost 144,83±61,08 luni. Toți copiii au primit tratament cu GCS, durata medie de administrare fiind 28,02±27,74 luni. 25-OH vitamina D totală a fost determinată prin metoda imunoenzimatică. Rezultate. Rezultatele obținute ar putea sta la baza realizării unor recomandări menite să prevină deficitul de vitamina D la copiii cu maladii cronice reumatice. Concluzii. Rezultatele obținute ar putea sta la baza realizării unor recomandări, menite să prevină deficitul de vitamina D la copiii cu maladii cronice reumatice.