Managementul hepatitei virale C acute

Abstract

Summary. The importance and necessity of the present study was imposed by the fact that a standard antiviral treatment was not elaborated in case of acute viral hepatitis C (AVHC). Taking into account the large percentage of chronicity of hepatitis with virus C, the treatment itself should be an antiviral one. To establish the effi ciency of combined antiviral treatment with pegasys and copegus, 40 patients with AVHC participated in the study, 12 of which were females (30%) and 28 males (70%) of average age 43,54 ±1,68 years old. To confi rm the diagnosis anamnesis, clinical, epidemiological and laboratory data have been analized. The haemoleucogram, biochemical tests of the liver (bilirubin, ALAT, thymol test, prothrombin), the markers of the viral C hepatitis (anti-VHC IgM, anti-VHC tot9) were investigated by excluding other viral hepatites (by determining the viral B and D hepatites markers), the abdominal ecography and the ARN-VHC by PCR. A combined antiviral treatment was initiated with pegasys+copegus. The clinical symptomatology of the patients in the study was demonstrated by symptoms of dispeptic asthenic and arthralgic symptoms. The contamination occured mainly paranterally. The treatment with pegasys + copegus was effi cient (SVR – 100%) and can be recommended for acute forms of hepatitis C.

Резюме. Актуальность проводимых исследований состоит в том, что до сих пор не разработан стандарт противовирусного лечения острого вирусного гепатита С (ОВТС). Под наблюдением находились 40 больных с ОВГС – 12 женщин и 28 мужчин, у которых диагноз установлен на основании биохимических, серологических и молекулярно-биологических методов исследования. Было назначено комбинированное лечение пегасисом и копегусом. Пегасис – 180 мкг в неделю в.м. а копегус – в дозе 1000 – 1200 мг в день, в зависимости от веса. Длительность лечения – от 12, 24 и 48 недель. Лечение пегасисом и копегусом было эффективным и привело к 100% выздоровлению и может быть рекомендовано для лечения острых форм гепатита С.