Abstract:
Abstract.
Background: Breast cancer is one of the three most common cancers along with lung and colon cancer. It is a leading cause of cancer deaths in both
developing and developed countries. Within 2 decades, neoadjuvant chemotherapy (NAC) has become a standard treatment option in breast cancer.
Relevant articles were identified by means of PubMed, Embase, Web of Science, Cochrane Library, and Springer Link databases published during the
years 2010-2019, describing the role of molecular biomarkers in the assessment of NAC for breast cancer.
Conclusions: The size of the breast primary tumor, the affection of the regional lymph nodes, the degree of tumor differentiation, the expression of
hormone receptors, HER2neu, ki67 serve as the main criteria for predicting the response to NAC. Preoperative core needle biopsy is the gold standard
procedure in cancer diagnostics, in the analysis of predictive biomarkers, particularly utilizing histomorphological characteristics. Carrying out a larger
number of cycles of NAC as well as correlating the schemes in relation to the immunohistochemical types have a direct influence on obtaining a good
response to treatment. Patients with a pathological complete response had superior survival outcomes compared with patients who had residual disease.
Description:
Department of Breast Cancer, Institute of Oncology, Chisinau, the Republic of Moldova
