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Cercetarea stabilităţii în timp real a picăturilor oftalmice extemporale, cu conţinut de nitrofural şi cloramfenicol

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dc.contributor.author Bolgar, Anastasia
dc.date.accessioned 2021-04-11T09:09:49Z
dc.date.available 2021-04-11T09:09:49Z
dc.date.issued 2017
dc.identifier.citation BOLGAR, Anastasia. Cercetarea stabilităţii în timp real a picăturilor oftalmice extemporale, cu conţinut de nitrofural şi cloramfenicol = The research of stability in real time of the ophthalmic drops prepared in pharmacies, containig nitrofurazone and chloramphenicol. In: Revista Farmaceutică a Moldovei. 2017, nr. 1-2, p. 28. ISSN 1812-5077. en_US
dc.identifier.issn 1812-5077
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/16637
dc.description Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova en_US
dc.description.abstract Introducere. De rând cu formele farmaceutice industriale, formele farmaceutice magistrale nu-şi pierd actualitatea, deoarece permit individualizarea tratamentului pentru fiecare pacient. Ordinul Nr.10 din 06.01.06 MS RM „Cu privire la supravegherea calităţii formelor medicamentoase preparate în farmacii”, nu prevede stabilirea termenelor de valabilitate pentru formele extemporale, din aceste considerente s-a propus studiul de stabilitate a două forme magistrale Scopul lucrării. Determinarea termenului de valabilitate în timp real, al picăturilor oftalmice cu conţinut de nitrofural şi al picăturilor oftalmice cu conţinut de cloramfenicol, izotonizate cu clorură de sodiu. Material şi metode. Pentru determinarea cantitativă a nitrofuralului s-a utilizat metoda fotocolorimetrică, iar pentru determinarea cantitativă a cloramfenicolului spectrofotometria. Cantitatea de clorură de sodiu s-a determinat prin metoda argentometrică. Rezultate. S-au preparat câte 3 serii de soluţie nitrofural 0,02% şi soluţie cloramfenicol 0,25%; care s-au ambalat corespunzător şi sterilizat timp de 30 minute la temperatura de 100°C. Studiul s-a efectuat în timp real, cu o periodicitate de 7 zile, în condiţii obişnuite (temperatura 25°C±2°C). Identificarea şi dozarea componentelor s-a realizat conform metodelor elaborate. Rezultatele determinărilor cantitative au fost prelucrate statistic. Eroarea relativă a mediei (E%) pentru nitrofural este 4,99, pentru cloramfenicol 1,68, iar pentru clorură de sodiu 1,80. Concluzii. Pe parcursul a 60 de zile s-a testat stabilitatea picăturilor oftalmice cu conţinut de nitrofural şi cloramfenicol. Termenul de valabilitate propus pentru formele date este egal cu 2 luni. en_US
dc.description.abstract Introduction. The magistral pharmaceutical preparations remain their actuality along with the industrial pharmaceutical preparations, as it enables the individualization of treatment for each patient. The Moldovan Health Ministry’s order JV2IO dated 06.01.2006 "On quality supervision of dosage forms prepared in pharmacies” does not provide the establishment of validity terms for extemporaneous preparations, thus it was proposed to study the stability of two magistral preparations. The aim of the study. To establish the validity term of the ophthalmic drops with nitrofurazone and ophthalmic drops with chloramphenicol, isotonised with sodium chloride in real time. Material and methods. For establishing the quantity of nitrofurazone, the photocolorimetric method was used, while for establishing the quantity of chloramphenicol, the spectrophotometry was used. The quantity of sodium chloride was determined by argentometry method. Results. 3 series of 0,02% nitrofurazone solution and 0,25% chloramphenicol solution were prepared, properly packaged and sterilized for 30 min. at the temperature of 100°C degrees. The research was conducted in real time with periodicity of 7 days, in ordinary conditions (temperature of 25°C±2°C). The identification and assay of components were performed in accordance with the elaborated methods. The result of the quantity determinations were statistically processed. The relative error of medium (E%) for nitrofurazone is 4,99, for chloramphenicol 1,68 and for the sodium chloride 1,80. Conclusions. It has been tested the stability of ophthalmological drops with nitrofurazone with chloramphenicol during 60 days. The validity term of these preparations is 2 months. en_US
dc.publisher Asociația Farmaciștilor din Republica Moldova en_US
dc.relation.ispartof Revista Farmaceutică a Moldovei: The First Congress of Pharmaceutical Students Association from Republic of Moldova dedicated to the Year Nicolae Testemitanu "Innovation and creativity in pharmaceutical practice and research”, May 4-7, 2017, Chisinau, Republic of Moldova en_US
dc.subject magistral form en_US
dc.subject eye drops en_US
dc.subject stability en_US
dc.subject validity term en_US
dc.title Cercetarea stabilităţii în timp real a picăturilor oftalmice extemporale, cu conţinut de nitrofural şi cloramfenicol en_US
dc.title.alternative The research of stability in real time of the ophthalmic drops prepared in pharmacies, containig nitrofurazone and chloramphenicol en_US
dc.type Article en_US


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  • Revista Farmaceutică a Moldovei Nr. 1-2, 2017
    Materials of First Congress of Pharmaceutical Students Association from Republic of Moldova dedicated to the Year Nicolae Testemitanu "Innovation and creativity in pharmaceutical practice and research”, May 4-7, 2017, Chisinau, Republic of Moldova

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