The impact of antibiotics in inducing inflammatory bowel diseases to children

Abstract

Background. The etiopathogenesis of inflammatory bowel disease remains ambiguous, today being discussed as a combination of genetic modification and as immunological disorders caused by enteric microflora interaction with the enteric mucous membrane, that damages it later. But the role of antibiotics in the enteric microflora changes and the activation of ulcerative colitis and Crohn’s disease require further studies, especially to children of early age. Objectives. The interrelationship estimation of antibiotics for children in the first year of life, and the nascency of inflammatory bowel disease. Material and methods. The study was prospective and included patients admitted to the Gastroenterology Department, Mother and Child’s Institute, during 2010-2012, with a diagnosis of ulcerative colitis or Crohn’s disease, endoscopically and histologically confirmed. The role of antibiotics in inflammatory bowel disease was assessed follow-up lots of inquests, as well as by examining ambulatory cards, as well noting the pharmacological group of the antibiotic, the dose, the duration of therapy and the number of treatments. Results. The study involved 41 children with ulcerative colitis, 36 (87.8%) and Crohn’s disease 5 (12.2%) with a mean age of 72 ± 23.93 months. Antibiotics were observed in 16 children (39.02%), cephalosporin group, generation II (62.5%) and third generation (37.5%). In 9 cases (56.25%) drug dose was increased, not adjusted to the child’s age. The mean duration of therapy was 6.73 ± 1.65 days, and the average number of cures administered was 2.12 ± 0.5 courses. Conclusion. The impact of antibiotics in inflammatory bowel disease outbreak is irrevocable, particularly ulcerative colitis and administration, mainly cephalosporin, in the first year of life in overdose and in repeated courses is directly related with early appearance and evolution of inflammatory bowel disease to children.