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Serum levels of interleukin’s in children with acute M. Pneumoniae bronhoobstructive diseases

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dc.contributor.author Sciuca, S.
dc.contributor.author Neamtu, L.
dc.contributor.author Magalu, V.
dc.date.accessioned 2021-06-14T13:00:44Z
dc.date.available 2021-06-14T13:00:44Z
dc.date.issued 2013
dc.identifier.citation SCIUCA, S., NEAMTU, L., MAGALU, V. Serum levels of interleukin’s in children with acute M. Pneumoniae bronhoobstructive diseases. In: Buletin de perinatologie. 2013, nr. 2-3(58-59), p. 319. ISSN 1810-5289. en_US
dc.identifier.issn 1810-5289
dc.identifier.uri https://www.mama-copilul.md/images/buletin-perinatologic/BP_2013/2_2013.pdf
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/17813
dc.description Departament of Pediatrics, State Medical and Pharmaceutical University “Nicolai Testimitanu”, Republic of Moldova, Laboratory of Immunology, Institute for Maternal and Child Health Care en_US
dc.description.abstract Background. Mycoplasma pneumoniae is an important etiological agent responsible for children’s respiratory tract diseases. The role of cytokines in mycoplasma infections has gained much attention. IL-2 is normally produced by T cells during an immune response. Aim of our study was to evaluate changes of IL-2, IL-4 in peripheral blood in children with Mycoplasma pneumoniae bronhoobstructive diseases. Methods. The study included 33 children, aged 6 months - 7 years, with pneumonia and wheezing for evaluation of changes of IL-2, IL-4 in peripheral blood in acute Mycoplasma pneumoniae infection. Levels of Mycoplasma pneumoniae-specific antibodies (IgM, IgG), the peripheral blood concentrations of IL-2, IL-4 were determined in serum samples obtained at enrollment from all 33 children that were tested by ELISA. Results. There were two study visits: first in admission and second – after 1 month. 20 patients completed study group with Mycoplasma-positive infection and 13 children completed control group - Mycoplasma-negative infection. IL-2 levels in children with Mycoplasma-positive bronchopulmonary disease was 31,80±2,26 pg/ml and in Mycoplasma-negative group 39,27±3,17 pg/ml, IL-4 levels was 46,92±2,93 pg/ml versus 52,36±2,17pg/ml, respectively. After 1 month in mycoplasma-positive group levels of IL-2 had increased (39,68±6,84pg/ml). No significant changes were observed in values of IL-4 in the period of one month after the admission (47,75±2,19 pg/ml). Conclusion. There was an imbalance of served disorders of immune response with significant decreasing levels of IL-2 and to a lesser extent of IL-4 in children with M.pneumoniae infection at the acute phase in our study, suggesting necessity of administration of therapeutic program for control of infectious inflammatory process in Mycoplasmal bronhoobstructive diseases. en_US
dc.language.iso en en_US
dc.publisher Instituţia Medico-Sanitară Publică Institutul Mamei și Copilului en_US
dc.relation.ispartof Buletin de perinatologie: Congresul V al Federaţiei Pediatrilor Ţărilor CSI şi Congresul VI al Pediatrilor şi Neonatologilor din Republica Moldova, 22-24 mai 2013, Chișinău, Republica Moldova en_US
dc.subject Mycoplasma infection en_US
dc.subject bronchoobstructive deseases en_US
dc.subject interleukin’s levels en_US
dc.title Serum levels of interleukin’s in children with acute M. Pneumoniae bronhoobstructive diseases en_US
dc.type Other en_US


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  • Buletin de Perinatologie Nr. 2-3(58-59) 2013
    Materialele Congresului V al Federaţiei Pediatrilor Țărilor CSI și Congresului VI al Pediatrilor și Neonatologilor din Republica Moldova, 22-24 mai 2013, Chișinău, Republica Moldova

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