Abstract:
In recent years allergy became one of the most pressing problems of pediatrics. It is noted increase in the number of cases among infants. Primary and secondary prevention of allergic reactions and disease - an important direction to reduce allergic diseases in children and adolescents. It is carried out in children with the risk of allergic disease. However, preventive measures in the families at risk ”should begin before birth, optimally - at the planning stage of pregnancy. The aim of the study was to test the concept of perinatal prevention of allergic diseases in children with the application of Lactobacillus rhamnosus LGG in pregnant women and infants at risk of developing allergies. A comparative controlled study was conducted in parallel groups, selected by a stratified randomization to nozoform of 102 pregnant women with various allergic manifestations in history, or at the time o f the study. The first main group consisted of 33 pregnant women at 35-36 weeks of gestation were treated or ally with 1.5 billion viable bacteria Lactobacillus rhamnosus LGG per day for 20 days. Their children also received this bacteria culture for 20 days. In the second main group included 34 pregnant women and 34 newborns who received twenty-day course of one billionviable bacteria Lactobacillus rhamnosus LGG orally. The control group consisted of3 5 pregnant women and 35 infants who did not receive studied medical ion. By the age off our months allergy in the first group were observed in 15.15 % of children at the same time in the second group - 44.11 %, in the control group -57.14 % of children. The most effective statistical model should be noted first group of patients studied. In patients receiving Lactobacillus rhamnosus LGG in pregnant women and newborns observed decrease in the frequency and severity of allergic diseases in children.
Description:
Кафедра Педиатрии N°1, Неонатологии и Биоэтики, Одесский Национальный Медицинский Университет, Одесса, Украина
