Microscopic changes in blood capillaries in hemorrhagic vasculitis and the correlation with the degree of expression of immune reactions

Abstract

Introduction: Henoch-Schoenlein Purpura is the most frequent vasculitis in pediatric patients usually with a self-limiting evolution. Still the evolution of the disease is hardly predictable with a possibility to acquire a severe clinical form. This paper had the goal to highlight the possible correlation between the severity of the degree of the histopathological lesions and the expression of markers of endothelial status and cellular and humoral immune status. Other researches with similar purpose were performed, but the analysis of the literature has shown that the results are contradictory. Materials and Methods: To reach the goal, we have performed histopathological diagnosis and analysis of skin biopsies and we have evaluated the endothelial status, cellular immune status and humoral immune status. Results: We founded a significant correlation between the degree of implication of microcirculation and the level of markers of the endothelial status. Conclusions: The markers of the endothelial activation can be an alternative method in evaluation o f the severity of disease and therefore of the therapeutical strategy, still more researches are necessary.