Abstract:
Background: Acute disseminated encephalomyelitis (ADEM), possibly demyelinating is an acute, rapidly progressive autoimmune process
characterized by CNS demyelination (frequently associated with involvement of optic nerves) due to immune-mediated inflammation, which
requires rapid diagnosis and selection of appropriate early treatment. The aim of the studywas to present an unusual case of ADEM with bilateral
involvement of optic nerves.
Material and methods: A case study presentation.
Results: Case report study of a 47-year-old man presented with progressive loss of vision in both eyes, numbness in the upper and lower limbs,
static and gait disorders, urinary retention. The clinical onset was preceded by a Covid-19 infection 3 weeks before presentation. ENG demonstrated
sensitive axonal polyneuropathy, brain MRI – demyelination in left frontal lobe area; cervical and thoracic contrast MRI – without pathological
changes, visual evoked potentials results suggestive of prechiasmic demyelinating involvement on the right side, lumbar puncture – impossible to
perform, ophthalmological examination – neuroophthalmopathy of unknown etiology, anti-MOG, anti-AQP4 antibodies – negative. Progressive
evolution of the disease, following the first-line treatment (Prednizolon 500 mg, N8) and plasmapheresis. Home discharge with second-line
treatment with Azathioprine 50 mg without positive dynamics.
Conclusions: The presented case of ADEM proved no therapeutic effects to plasmapheresis and immunosuppressive treatment in spite
of its autoimmune pathogenesis. Other therapy options to be considered: mofetil mycophenolate, IV IG, calcineurin inhibitors or other
immunomodulatory agents.
