Abstract:
Introduction: NHL (non-Hodgkin lymphomas) are malignant tumors that develop from
hematopoietic cells located extramedullary, heterogeneous in terms of morphology and biology.
They are the most common malignancies of the hematopoietic system. Of all primary tumors
recorded annually, NHL are diagnosed in 5% of males and in 4% of females. Impairment in primary
gastric NHL meets quite often. Extranodal location of NHL is recorded in 42% of cases. One of the
most eliminates frequent extranodal localization is the gastrointestinal tract (13.3%). Different
effect on different compartments eliminates frequent gastrointestinal tract: the stomach eliminates
frequent being affected - in 70-75% of cases.
Purpose and Objectives: to study the clinical aspects and treatment results in impaired
primary gastric NHL.
Materials and methods: The outpatients records were studied in 84 patients diagnosed with
non-Hodgkin lymphoma (NHL) with primary involvement of the stomach, which is registered by
the haematologists at the Institute of Oncology in the period 2000 - 2013. Of 84 patients diagnosed
with primary gastric NHL, females with 48 and males - 36, with a median age of 57 years.
Results: NHL with primary involvement of the stomach developed frequently in people aged
between 51-70 years (50%) and were rarely diagnosed at the age 19-30 years (3.6%). The common
location of gastric NHL, was the stomach body (42.8%). In the primary NHL damage of the
stomach have been mainly developed aggressive variants (85.7%). Regardless, morphological
structure, gastric NHL initially spread in to the lymph abdominal nodes. Extranodal metastases
occurred mainly in the liver, spleen, different regions of the tract gastrointestinal. The efficacy of
the treatment in gastric NHL depended on the stage of tumor. Gastric resection is an important
component in the combined treatment of primary gastric NHL damage.
Conclusions: In primary gastric NHL damage regardless, morphological variant, age and
disease stage optimal method of management is combined treatment: Surgical + Radiotherapy +
Combined chemotherapy.
